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It means stepping back one dose level, allowing your nervous system to adapt, and then cautiously resuming escalation after 2 to 4 weeks

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Ensuring equitable access to these effective but high-cost medications, as well as supporting individuals so that they can stay on the therapy long-term, should be a priority for our clinicians and policymakers. The findings, which were presented at the American Heart Association Scientific Sessions and simultaneously published in JAMA Cardiology, underscore the need to increase equitable access to this new class of pharmaceuticals

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JAMA Network Open 2018, 1: e182777